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anti-Adiponectin Receptor AdipoR1 C-terminus
Specifications
Applications
Peptide sequence is < 50 % identical to other receptors in this region. The antibody recognizes AdipoR1 in multiple species since the sequence region recognized by the antibody is highly conserved.
Sequence Alignment between human, mouse and rat:
345VAAAFVHFYGVSNLQEFRYGLEGGC369Human
345VAAAFVHFYGVSNLQEFRYGLEGGC369Mouse
345VAAAFVHFYGVSNLQEFRYGLEGGC369Rat
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006 Jul;116(7):1784-92. Full Text
Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B. Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring). 2006 Jan;14(1):28-35. Full Text
Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Peterfi C, Weisser M, Machicao F, Stumvoll M, Haring HU. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes. 2004 Sep;53(9):2195-201. Full Text
Yamauchi T, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9. Abstract