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Print Datasheetanti-Adiponectin Receptor AdipoR2 C-terminus
IH paraffin section mouse muscle with anti-Adipo R2 N-terminal region antibody (Top)
IH paraffin section mouse liver with anti-Adipo R2 N-terminal region antibody (Bottom)
Specifications
Applications
Adiponectin receptor 2 (AdipoR2) is an integral membrane protein with seven transmembrane domains with an internal N-terminus and an external C-terminus. AdipoR2 is highly conserved among species and expressed mainly in the liver and skeletal muscle. Expression of AdipoR2 in the brain correlates with brain development and size in mice.
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Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006 Jul;116(7):1784-92. Full Text
Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B. Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring). 2006 Jan;14(1):28-35. Full Text
Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, Peterfi C, Weisser M, Machicao F, Stumvoll M, Haring HU. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes. 2004 Sep;53(9):2195-201. Full Text
Yamauchi T, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003 Jun 12;423(6941):762-9. Abstract
