anti-human TRAIL-R2
$345.00
Amount: 200 ug
Synonyms: tumor necrosis factor receptor superfamily member 10B precursor, death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, and CD262 antigen
Specifications
Host Species: Goat
Antigen: Synthetic peptide 68APQQKRSSPSEGLCPPGHHISEDGRDC94 of the extracellular domain of human TRAIL-R2 (DR5)
Reactive Species: Human, Mouse
Format/Conjugates/Purification: Affinity Purification
Buffer & Formulation: Affinity purified antibody @ 1mg/ml in 10 mM KHPO4, 140 mM NaCl with BSA @ 1mg/ml and 0.1 % sodium azide
Storage: Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
Clone: Polyclonal
Applications
ELISA: 1:75,000
Western Blotting: 1:500
IHC: 1:150
Flow Cytometry: 2ul/10^6 cells/100ul
References
Babu CK, Suwansrinon K, Bren GD, Badley AD,Rizza SA. HIV induces TRAIL sensitivity in hepatocytes. PLoS ONE.2009;4(2):e4623. Epub 2009 Feb 27. Full Text WB
SanliogluAD, Korcum AF, Pestereli E, Erdogan G, Karaveli S, Savas B, GriffithTS, Sanlioglu S. TRAIL death receptor-4 expression positivelycorrelates with the tumor grade in breast cancer patients with invasiveductal carcinoma. Int J Radiat Oncol Biol Phys. 2007 Nov1;69(3):716-23. Abstract IH
AydinC, Sanlioglu AD, Karacay B, Ozbilim G, Dertsiz L, Ozbudak O, Akdis CA,Sanlioglu S. Decoy receptor-2 small interfering RNA (siRNA) strategyemploying three different siRNA constructs in combination defeatsadenovirus-transferred tumor necrosis factor-related apoptosis-inducingligand resistance in lung cancer cells. Hum Gene Ther. 2007Jan;18(1):39-50 Abstract IH
Hoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N,Lunemann JD, Aktas O, Mahrhofer C, Stricker S, Zipp F, Weber JR. TRAILlimits excessive host immune responses in bacterial meningitis. J ClinInvest. 2007 Jul;117(7):2004-13. Full Text FC 1:200 dilution
GantenTM, KHoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N,Lunemann JD, Aktas O, Mahrhofer C, Stricker S, Zipp F, Weber JR. TRAILlimits excessive host immune responses in bacterial meningitis. J ClinInvest. 2007 Jul;117(7):2004-13. Full Text FC
GantenTM, Koschny R, Haas TL, Sykora J, Li-Weber M, Herzer K, Walczak H.Proteasome inhibition sensitizes hepatocellular carcinoma cells, butnot human hepatocytes, to TRAIL. Hepatology. 2005 Sep;42(3):588-97. WB Abstract
ShahK, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.Glioma therapy and real-time imaging of neural precursor cell migrationand tumor regression. Ann Neurol. 2005 Jan;57(1):34-41. WB Full Text
GantenTM, Haas TL, Sykora J, Stahl H, Sprick MR, Fas SC, Krueger A, WeigandMA, Grosse-Wilde A, Stremmel W, Krammer PH, Walczak H. Enhancedcaspase-8 recruitment to and activation at the DISC is critical forsensitisation of human hepatocellular carcinoma cells to TRAIL-inducedapoptosis by chemotherapeutic drugs. Cell Death Differ. 2004 Jul;11Suppl 1:S86-96. WB Full Text
JinTG, Kurakin A, Benhaga N, Abe K, Mohseni M, Sandra F, Song K, Kay BK,Khosravi-Far R. Fas-associated protein with death domain(FADD)-independent recruitment of c-FLIPL to death receptor 5. J BiolChem. 2004 Dec 31;279(53):55594-601. WB Full Text
LaValleeTM, Zhan XH, Johnson MS, Herbstritt CJ, Swartz G, Williams MS,Hembrough WA, Green SJ, Pribluda VS.2-methoxyestradiol up-regulatesdeath receptor 5 and induces apoptosis through activation of theextrinsic pathway. Cancer Res. 2003 Jan 15;63(2):468-75. IH Full Text
HiguchiH, Yoon JH, Grambihler A, Werneburg N, Bronk SF, Gores GJ. Bile acidsstimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. JBiol Chem. 2003 Jan 3;278(1):454-61. IC, WB Full Text
HiguchiH, Bronk SF, Takikawa Y, Werneburg N, Takimoto R, El-Deiry W, GoresGJ. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5expression and apoptosis. J Biol Chem. 2001 Oct 19;276(42):38610-8. IC, WB Full Text
